ATP-binding cassette, sub-family G (WHITE), member 8
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
Gene aliases
STSL
Chromosome
2
Map location
2p21
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for ABCG8
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Sequence variants for ABCG8
List of cell lines/tissues that have ABCG8 sequence variants
List of pathways where ABCG8 is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for ABCG8
Network key
Number of sequence variations per gene
Protein identification for ABCG8
Browse by protein identification methods
| Identification method | Quantitative data available |
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