alcohol dehydrogenase 5 (class III), chi polypeptide
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
Gene aliases
ADH-3,
ADHX,
FALDH,
FDH,
GSNOR
Chromosome
4
Map location
4q23
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for ADH5
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Sequence variants for ADH5
List of cell lines/tissues that have ADH5 sequence variants
List of pathways where ADH5 is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for ADH5
Network key
Number of sequence variations per gene
Protein identification for ADH5
Browse by protein identification methods
| Identification method | Quantitative data available |
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