asialoglycoprotein receptor 1
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene aliases
ASGPR,
ASGPR1,
HL-1
Chromosome
17
Map location
17p13.2
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for ASGR1
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Sequence variants for ASGR1
List of cell lines/tissues that have ASGR1 sequence variants
List of pathways where ASGR1 is involved
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Protein-Protein Interaction Network for ASGR1
Network key
Number of sequence variations per gene
Protein identification for ASGR1
Browse by protein identification methods
| Identification method | Quantitative data available |
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