complement component 4 binding protein, beta
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene aliases
C4BP
Chromosome
1
Map location
1q32
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for C4BPB
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Sequence variants for C4BPB
List of cell lines/tissues that have C4BPB sequence variants
List of pathways where C4BPB is involved
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Protein-Protein Interaction Network for C4BPB
Network key
Number of sequence variations per gene
Protein identification for C4BPB
Browse by protein identification methods
| Identification method | Quantitative data available |
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