cyclin D1
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
Gene aliases
BCL1,
D11S287E,
U21B31
Chromosome
11
Map location
11q13
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for CCND1
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| PTMs | |
| Protein entries | |
| Sequence variants | |
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| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for CCND1
List of cell lines/tissues that have CCND1 sequence variants
List of pathways where CCND1 is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for CCND1
Network key
Number of sequence variations per gene
Protein identification for CCND1
Browse by protein identification methods
| Identification method | Quantitative data available |
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