cyclin D2
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
Gene aliases
MPPH3
Chromosome
12
Map location
12p13
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for CCND2
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Sequence variants for CCND2
List of cell lines/tissues that have CCND2 sequence variants
List of pathways where CCND2 is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for CCND2
Network key
Number of sequence variations per gene
Protein identification for CCND2
Browse by protein identification methods
| Identification method | Quantitative data available |
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