cell division cycle 6
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Gene aliases
CDC18L,
HsCDC6
Chromosome
17
Map location
17q21.3
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for CDC6
| Domains | |
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| PTMs | |
| Protein entries | |
| Sequence variants | |
| Cell lines/tissues | |
| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for CDC6
List of cell lines/tissues that have CDC6 sequence variants
List of pathways where CDC6 is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for CDC6
Network key
Number of sequence variations per gene
Protein identification for CDC6
Browse by protein identification methods
| Identification method | Quantitative data available |
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