cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene aliases
CDK4I,
INK4B,
MTS2,
P15,
p15INK4b
Chromosome
9
Map location
9p21
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for CDKN2B
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| PTMs | |
| Protein entries | |
| Sequence variants | |
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| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for CDKN2B
List of cell lines/tissues that have CDKN2B sequence variants
List of pathways where CDKN2B is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for CDKN2B
Network key
Number of sequence variations per gene
Protein identification for CDKN2B
Browse by protein identification methods
| Identification method | Quantitative data available |
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