DNA replication helicase/nuclease 2
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Gene aliases
hDNA2
Chromosome
10
Map location
10q21.3-q22.1
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for DNA2
| Domains | |
|---|---|
| PTMs | |
| Protein entries | |
| Sequence variants | |
| Cell lines/tissues | |
| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for DNA2
List of cell lines/tissues that have DNA2 sequence variants
List of pathways where DNA2 is involved
| Pathway name | Pathway source |
|---|
Protein-Protein Interaction Network for DNA2
Network key
Number of sequence variations per gene
Protein identification for DNA2
Browse by protein identification methods
| Identification method | Quantitative data available |
|---|