hemoglobin, beta
The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
Gene aliases
beta-globin
Chromosome
11
Map location
11p15.5
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for HBB
| Domains | |
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| PTMs | |
| Protein entries | |
| Sequence variants | |
| Cell lines/tissues | |
| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for HBB
List of cell lines/tissues that have HBB sequence variants
List of pathways where HBB is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for HBB
Network key
Number of sequence variations per gene
Protein identification for HBB
Browse by protein identification methods
| Identification method | Quantitative data available |
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