LCK proto-oncogene, Src family tyrosine kinase
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]
Gene aliases
IMD22,
LSK,
YT16,
pp58lck
Chromosome
1
Map location
1p34.3
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for LCK
| Domains | |
|---|---|
| PTMs | |
| Protein entries | |
| Sequence variants | |
| Cell lines/tissues | |
| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for LCK
List of cell lines/tissues that have LCK sequence variants
List of pathways where LCK is involved
| Pathway name | Pathway source |
|---|
Protein-Protein Interaction Network for LCK
Network key
Number of sequence variations per gene
Protein identification for LCK
Browse by protein identification methods
| Identification method | Quantitative data available |
|---|