minichromosome maintenance complex component 2
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
Gene aliases
BM28,
CCNL1,
CDCL1,
D3S3194,
cdc19
Chromosome
3
Map location
3q21
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for MCM2
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| PTMs | |
| Protein entries | |
| Sequence variants | |
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| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for MCM2
List of cell lines/tissues that have MCM2 sequence variants
List of pathways where MCM2 is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for MCM2
Network key
Number of sequence variations per gene
Protein identification for MCM2
Browse by protein identification methods
| Identification method | Quantitative data available |
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