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nuclear receptor coactivator 2

The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]
Gene official symbol
NCOA2

Entrez gene ID
10499

Gene aliases
GRIP1, KAT13C, NCoA-2, SRC2, bHLHe75

Chromosome
8

Map location
8q13.3

Gene type
protein-coding

Gene Ontology (GO) terms enrichment




Database references
601993
7669
ENSG00000140396
OTTHUMG00000164671
VP_10499
ENSG00000140396-NCOA2


Statistics for NCOA2

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Sequence variants
Cell lines/tissues
Pathways involved in
Protein-Protein Interactions



Sequence variants for NCOA2



List of cell lines/tissues that have NCOA2 sequence variants




List of pathways where NCOA2 is involved


Pathway name Pathway source

Protein-Protein Interaction Network for NCOA2



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Protein identification for NCOA2


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Identification method Quantitative data available

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Qualitative proteomic data





Post-translational modifications (PTMs) in NCOA2


Domains for NCOA2

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