peptidylprolyl isomerase A (cyclophilin A)
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
Gene aliases
CYPA,
HEL-S-69p
Chromosome
7
Map location
7p13
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for PPIA
| Domains | |
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| PTMs | |
| Protein entries | |
| Sequence variants | |
| Cell lines/tissues | |
| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for PPIA
List of cell lines/tissues that have PPIA sequence variants
List of pathways where PPIA is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for PPIA
Network key
Number of sequence variations per gene
Protein identification for PPIA
Browse by protein identification methods
| Identification method | Quantitative data available |
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