proteasome (prosome, macropain) 26S subunit, ATPase, 4
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene aliases
MIP224,
RPT3,
S6,
TBP7
Chromosome
19
Map location
19q13.11-q13.13
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for PSMC4
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| PTMs | |
| Protein entries | |
| Sequence variants | |
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| Protein-Protein Interactions |
Sequence variants for PSMC4
List of cell lines/tissues that have PSMC4 sequence variants
List of pathways where PSMC4 is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for PSMC4
Network key
Number of sequence variations per gene
Protein identification for PSMC4
Browse by protein identification methods
| Identification method | Quantitative data available |
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