signal-regulatory protein beta 1
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Gene aliases
SIRP-BETA-1
Chromosome
20
Map location
20p13
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for SIRPB1
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Sequence variants for SIRPB1
List of cell lines/tissues that have SIRPB1 sequence variants
List of pathways where SIRPB1 is involved
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Protein-Protein Interaction Network for SIRPB1
Network key
Number of sequence variations per gene
Protein identification for SIRPB1
Browse by protein identification methods
| Identification method | Quantitative data available |
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