suppressor of cytokine signaling 2
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene aliases
CIS2,
Cish2,
SOCS-2,
SSI-2,
STATI2
Chromosome
12
Map location
12q
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for SOCS2
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Sequence variants for SOCS2
List of cell lines/tissues that have SOCS2 sequence variants
List of pathways where SOCS2 is involved
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Protein-Protein Interaction Network for SOCS2
Network key
Number of sequence variations per gene
Protein identification for SOCS2
Browse by protein identification methods
| Identification method | Quantitative data available |
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