TTK protein kinase
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Gene aliases
CT96,
ESK,
MPH1,
MPS1,
PYT
Chromosome
6
Map location
6q14.1
Gene type
protein-coding
Gene Ontology (GO) terms enrichment
Database references
Statistics for TTK
| Domains | |
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| PTMs | |
| Protein entries | |
| Sequence variants | |
| Cell lines/tissues | |
| Pathways involved in | |
| Protein-Protein Interactions |
Sequence variants for TTK
List of cell lines/tissues that have TTK sequence variants
List of pathways where TTK is involved
| Pathway name | Pathway source |
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Protein-Protein Interaction Network for TTK
Network key
Number of sequence variations per gene
Protein identification for TTK
Browse by protein identification methods
| Identification method | Quantitative data available |
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